There are many that will suffer through life because they are stubborn and refuse to open their heart and mind to listen to God. Maybe there is some unconfessed sin that has to be dealt with or some other character flaw.
All it takes is asking God for help by accepting Christ into the heart which is the main thought from this song: The Heart of Worship – Matt Redman.
Trust in the Lord with all your heart and lean not on your own understanding; in all your ways submit to him, and he will make your paths straight. - Proverbs 3:5-6